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===What We Don't Know===
# How does oxygen affect THP production biochemically?
# How much oxygen has an effect; , and is there a maximum amount of dissolved oxygen that would be insignificant in its production?
# Does [[Aging_and_Storage#Bottle_Orientation|bottle orientation]] during storage have an effect?
# Does creating an [[Packaging#Acid_Shock_Starters|acid tolerance starter]] for conditioning yeast affect THP production?